5. Br J Dermatol 1980;103:411-5. Brooks, W. A., Santosham, M., Roy, S. K., Faruque, A. S., Wahed, M. A., Nahar, K., Khan, A. I., Khan, A. F., Fuchs, G. J., and Black, R. E. Efficacy of zinc in young infants with acute watery diarrhea. J Reprod Med 1080;25:150. J Health Popul.Nutr 2008;26(2):151-162. Leonard MB, Zemel BS, Kawchak DA, et al. Hemil H, Petrus EJ, Fitzgerald JT, Prasad A. Zinc acetate lozenges for treating the common cold: an individual patient data meta-analysis. However, its important not to exceed the upper limit of 40 mg of zinc per day, as consuming high amounts could cause digestive issues and flu-like symptoms, decrease copper absorption, and reduce the effectiveness of certain antibiotics. Taking zinc by mouth does not seem to help treat IBD. Iannotti, L. L., Zavaleta, N., Leon, Z., Shankar, A. H., and Caulfield, L. E. Maternal zinc supplementation and growth in Peruvian infants. View abstract. As such, they could potentially help prevent heart disease (19). Palomo F, Wantland L, Sanchez A, Volpe AR, McCool J, DeVizio W. The effect of three commercially available dentifrices containing triclosan on supragingival plaque formation and gingivitis: a six month clinical study. Int.J Dermatol. View abstract. Zinc deficiency in anorexia nervosa. BMC Pregnancy Childbirth. Afzali A, Goli S, Moravveji A, Bagheri H, Mirhosseini S, Ebrahimi H. The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial. View abstract. Br.Med J 5-28-1977;1(6073):1390-1391. View abstract. Bellamy, P. G., Jhaj, R., Mussett, A. J., Barker, M. L., Klukowska, M., and White, D. J. Basnet S, Shrestha PS, Sharma A, Mathisen M, Prasai R, Bhandari N, Adhikari RK, Sommerfelt H, Valentiner-Branth P, Strand TA; Zinc Severe Pneumonia Study Group. Rev.Esp.Enferm.Dig. Epilepsia 1992;33:555-7. Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine. High folate intakes related to zinc status in preterm infants. Understanding Normal and Clinical Nutrition. Experimental basis for increasing the therapeutic index of cis-diamminedicarboxylatocyclobutaneplatinum(II) in brain tumor therapy by a high-zinc diet. View abstract. Do zinc supplements enhance the clinical efficacy of hydroxychloroquine? View abstract. Lancet 3-17-2007;369(9565):927-934. J Affect Disord 1999;56:189-94. Warts. Rittenhouse T. The management of lower-extremity ulcers with zinc-saline wet dressings versus normal saline wet dressings. Intake of vitamin C and zinc and risk of common cold: a cohort study. Yuen WC, Whiteoak R, Thompson RP. Turner RB. View abstract. Staub E, Evers K, Askie LM. Prasad AS, Beck FW, Kaplan J, et al. Taking zinc with tetracyclines might decrease the effects of tetracyclines. Relea P, Revilla M, Ripoll E, et al. Dalgic, N., Sancar, M., Bayraktar, B., Pullu, M., and Hasim, O. Probiotic, zinc and lactose-free formula in children with rotavirus diarrhea: are they effective? Br J Dermatol 1989;121:497-502. J Int Med Res 1992;20:234-6. Comparison of zinc concentrations in blood and seminal plasma and the various sperm parameters between fertile and infertile men. Cadmium in zinc-containing mineral supplements. Soc Sci Med 2007;64(3):701-712. Asian Pac J Cancer Prev 2021;22(9):2879-2887. Maternal Zinc, Copper, and Selenium Intakes during Pregnancy and Congenital Heart Defects. A randomized double-blind placebo-controlled clinical trial. View abstract. Aydinok Y, Coker C, Kavakli K, et al. Curr Ther Res 1983;34:205-16. Cochrane Database Syst Rev. View abstract. Fairbrother, K. J., Kowolik, M. J., Curzon, M. E., Muller, I., McKeown, S., Hill, C. M., Hannigan, C., Bartizek, R. D., and White, D. J. View abstract. Signs of an allergic reaction, like rash. 2021;4(2):e210369. Prostate cancer. Lin, L. C., Que, J., Lin, K. L., Leung, H. W., Lu, C. L., and Chang, C. H. Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study. Am J Hematol 1999;61:194-202. View abstract. View abstract. View abstract. Shankar, A. H., Genton, B., Baisor, M., Paino, J., Tamja, S., Adiguma, T., Wu, L., Rare, L., Bannon, D., Tielsch, J. M., West, K. P., Jr., and Alpers, M. P. The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea. View abstract. To avoid this interaction, take antibiotics at least 2 hours before or 4-6 hours after zinc supplements. Taking zinc acexamate by mouth seems to help treat and prevent stomach ulcers. Borroni G, Brazzelli V, Vignati G, et al. 2012 Apr;43(4):313-7. 2020;19(1):101. J Med Assoc Thai 1995;78(7):344-349. Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Sorensen JA, Andersen O. A., Lewin, S. R., Wightman, F., Lee, M., Ravindran, T. S., and Paton, N. I. Zinc absorption in adult humans: the effect of iron fortification. A., Bhandari, N., Teka, T., Shahid, F., Taneja, S., and Black, R. E. Zinc during and in convalescence from diarrhea has no demonstrable effect on subsequent morbidity and anthropometric status among infants <6 mo of age. View abstract. View abstract. Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrations. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. Lagiou P, Wuu J, Trichopoulou A, et al. Effects of iron, tin, and copper on zinc absorption in humans. McBride K, Slotnick B, Margolis FL. Nutrition 2021;91-92:111418. Am J Perinatol 2020 Dec 7. doi: 10.1055/s-0040-1721659. St. Louis: Facts and Comparisons, 1998. Effects of zinc treatment in patients with recurrent aphthous stomatitis. Int J Neurosci 1990;50:103-7.. View abstract. Am J Hypertens 1988;1:303S-8S. View abstract. View abstract. Stevia in the Raw was introduced to the sweetener market several decades ago as a low-calorie alternative to traditional processed sugar. View abstract. Leitzmann MF, Stampfer MJ, Wu K, et al. View abstract. Endocr Metab Immune Disord Drug Targets. Am J Clin Nutr 1984;39:535-9. A randomized comparative trial of Varidase and zinc oxide. 1993;50(10):1007-1008. Terrin G, Berni Canani R, Passariello A, Messina F, Conti MG, Caoci S, Smaldore A, Bertino E, De Curtis M. Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country. "There was no convincing evidence that non-nutritive sweeteners had any effect in adults on eating behavior, cancer, cardiovascular disease, kidney disease, mood, behavior or cognition. Lang, C. J., Rabas-Kolominsky, P., Engelhardt, A., Kobras, G., and Konig, H. J. Zinc in depression: a meta-analysis. Mossad SB, Macknin ML, Medendorp SV, Mason P. Zinc gluconate lozenges for treating the common cold. View abstract. Micronutrient supplementation in the AIDS diarrhea-wasting syndrome in Zambia: a randomized controlled trial. Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS. Fatemi SH, Calabrese JR. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. View abstract. Am J Clin Nutr 1984;40:536-41.. View abstract. Zumkley H, Bertram HP, Preusser P, et al. View abstract. Serum and hair zinc levels in epileptic children taking valproic acid. If you decide on taking mineral supplements for one or more reasons, it is very important that you consult your doctor first and report whatever zinc side effects you experience. Abu-Hamdan DK, Desai H, Sondheimer J, et al. View abstract. J Gastroenterol Hepatol 1994;9:472-7. 2013 Oct;98(4):960-71. Nachnani, S. Reduction of oral malodor with Zinc containing Chewing gum(abstract). Randomized, controlled trial of zinc supplementation in malnourished Bangladeshi children with acute diarrhea. Friis, H., Ndhlovu, P., Mduluza, T., Kaondera, K., Sandstrom, B., Michaelsen, K. F., Vennervald, B. J., and Christensen, N. O. Agren MS. Studies on zinc in wound healing. Von Hoff DD. It's been used for over a . Gibson RS. 2016;115(5):807-16. J Nutr 1987;117:321-7. View abstract. View abstract. Zinc as an adjunct to antibiotics for the treatment of severe pneumonia in children <5 years: a meta-analysis of randomised-controlled trials. Taking zinc by mouth in combination with anti-leprosy drugs seems to help treat leprosy. Mazaheri Nia L, Iravani M, Abedi P, Cheraghian B. Abd-Elsalam S, Soliman S, Esmail ES, et al. Acta Paediatr 1999;88:154-60. Effect of zinc supplementation on clinical course of acute diarrhoea. Effect of zinc therapy on natural killer cell activity in inflammatory bowel disease. Clin Ther 1999;21:3-40. Pierard-Franchimont C, Goffin V, Visser JN, et al. View abstract. Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. View abstract. J Nutr Biochem. Synergistic effect of zinc and vitamin A on the biochemical indexes of vitamin A nutrition in children. These various forms of zinc affect your health in distinct ways. Here are 7 signs and symptoms of zinc overdose. 2012;4(7):648-675. Penttila O, Hurme H, Neuvonen PJ. J Pediatr. Kimmel, P. Zinc and chronic renal disease. 8. View abstract. Cochrane.Database.Syst.Rev. Ninh, N. X., Thissen, J. P., Collette, L., Gerard, G., Khoi, H. H., and Ketelslegers, J. M. Zinc supplementation increases growth and circulating insulin-like growth factor I (IGF-I) in growth-retarded Vietnamese children. View abstract. Gibson RS, Yeudall F, Drost N, et al. Clin Chem 1996;42:1938-42. Evaluation of oral zinc sulfate effect on obsessive-compulsive disorder: a randomized placebo-controlled clinical trial. Indian J Palliat Care. Available at: https://online.wsj.com/article/SB124516778692319231.html#mod=djemHL?mg=com-wsj (Accessed 16 June 2009). This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. Last medically reviewed on January 18, 2022. Horm Metab Res 1985;17;256-8. View abstract. The safety of sucralose at high . 2020. View abstract. Pediatrics 2008;121(2):326-336. A disorder of zinc deficiency (acrodermatitis enteropathica). 1979;59(4):368-370. Nowak, G., Siwek, M., Dudek, D., Zieba, A., and Pilc, A. Zinc intake and risk of prostate cancer: Case-control study and meta-analysis. 2013 Jul 18;122(3):311. Medically reviewed by Drugs.com. J Am Geriatr Soc 1998;46:19-26. Want to use it in a meal plan? View abstract. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. View abstract. Lomaestro BM, Bailie GR. View abstract. J Nutr 2002;132:697-702. Klin.Wochenschr. J.Clin.Dent. Zinc metabolism in patients treated with captopril versus enalapril. Br J Clin Pharmacol. 1991;28(1):11-19. Katz RL, Keen CL, Litt IF, et al. 2021; 79(1):1-12. Silva M, Montes CG, Canals A, Mackenna MJ, Wolff M. Role and effects of zinc supplementation in HIV-infected patients with immunovirological discordance: A randomized, double blind, case control study. Smith JC, Brown ED. People with restrictive diets, impaired nutrient absorption, or certain health conditions may be more susceptible (1). Int J Dermatol. J.Clin.Periodontol. View abstract. Sugar substitutes. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. Shah, D. R., Singh, P. P., Gupta, R. C., and Bhandari, T. K. Effect of oral zinc sulphate on serum lipids and lipoproteins in human subjects. Janyajirawong R, Vilaichone RK, Sethasine S. Efficacy of zinc supplement in minimal hepatic encephalopathy: A prospective, randomized controlled study (Zinc-MHE Trial). One review reported that low zinc levels could be linked to impaired blood sugar levels and type 2 diabetes (12). Licastro F, Chiricolo M, Mocchegiani E, et al. Vehapoglu A. Eby GA. Zinc ion availability--the determinant of efficacy in zinc lozenge treatment of common colds. View abstract. Zinc. Hambidge, K. M., Miller, L. V., Westcott, J. E., Sheng, X., and Krebs, N. F. Zinc bioavailability and homeostasis. Yunice AA, Czerwinski AW, Lindeman RD. Dermatology 2004;209(1):46-49. View abstract. 1990;10(1):63-69. http://ods.od.nih.gov/factsheets/Zinc-QuickFacts/" (2012): 3. Lancet 10-31-1970;2(7679):891-892. View abstract. 1997;34(7):589-597. Cochrane Database Syst Rev 2010;(6):CD008563. Fortes C, Forastiere F, Agabiti N, et al. View abstract. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. The effects of thiazides on serum and urinary zinc in patients with renal calculi. Though zinc is important in facilitating many bodily functions, zinc side effects can occur if you do not take it as advised. View abstract. Liukko P, Erkkola R, Pakarinen P, et al. Trace Elements in Human Health and Disease. Taking zinc by mouth does not improve sexual function in males with sexual dysfunction related to kidney disease. Dreno B, Trossaert M, Boiteau HL, Litoux P. Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. Am.J.Clin.Nutr. Vecchio, M., Navaneethan, S. D., Johnson, D. W., Lucisano, G., Graziano, G., Querques, M., Saglimbene, V., Ruospo, M., Bonifati, C., Jannini, E. A., and Strippoli, G. F. Treatment options for sexual dysfunction in patients with chronic kidney disease: a systematic review of randomized controlled trials. Am J Clin Nutr 2006;83(6):1401-1410. Toxicol Appl Pharmacol 1982;63:344-50. Am J Clin Nutr 1998;68:484s-7s. View abstract. View abstract. View abstract. Azizollahi G, Azizollahi S, Babaei H, Kianinejad M, Baneshi MR, Nematollahi-mahani SN. Inorganic zinc and the intestinal absorption of ferrous iron. Murphy, J. V. Intoxication following ingestion of elemental zinc. Causing symptoms such as loss of appetite, nausea, vomiting, diarrhea, and destruction of white blood cells, zinc toxicity usually occurs when someone has drunk large quantities of an acidic beverage, such as orange juice, from a galvanized (zinc lined) container, releasing 800 to 2,000 mg of zinc per day, or more.if(typeof ez_ad_units != 'undefined'){ez_ad_units.push([[250,250],'healthifybody_com-large-leaderboard-2','ezslot_0',122,'0','0'])};__ez_fad_position('div-gpt-ad-healthifybody_com-large-leaderboard-2-0'); Fortunately, the symptoms of acute zinc poisoning usually abate within 24 to 72 hours of withdrawing the source of excess zinc from the diet. 52nd ed. Clin Nephrol 1981;16:181-7. 1991;27:104-114. 2021;11(11):e047474. 2013 Oct;45(4):259-64. View abstract. Clin Rheumatol 1998;17:378-82. After a few weeks, Susan found that she needed a cane to steady herself even to walk across a room in her home. Zinc supplementation for improving pregnancy and infant outcome. Ironically, many Chronic Kidney Disease and Diabetic patients avoid artificial sweeteners because of popularized studies describing how the sweeteners lead to Gastrointestinal (stomach) problems, Migraines, Seizures, Dizziness, Blurred vision, Allergic reactions, Blood sugar increases, and even Weight gain. AREDS report no. Clin Neurol Neurosurg. Gastrointestinal problems: Additionally, artificial sweeteners are known to cause gastrointestinal problems such as abdominal pain, bloating, and diarrhea. View abstract. Am J Clin Nutr 2008;88(4):1067-1073. Moran, J., Newcombe, R. G., Wright, P., Haywood, J., Marlow, I., and Addy, M. A study into the plaque-inhibitory activity of experimental toothpaste formulations containing antimicrobial agents. A., Nizami, S. Q., and Isani, Z. Zinc supplementation in malnourished children with persistent diarrhea in Pakistan. Does hair zinc predict amphetamine improvement of ADD/hyperactivity? Eur J Nutr 2021. View abstract. Giving zinc by mouth to infants or children at risk for having low levels of zinc doesn't seem to improve development. View abstract. J Nutr 1995;125:66-72. View abstract. Bosch, F. and Jimenez, E. Post-marketing surveillance of zinc acexamate in peptic ulcer treatment. Ellul-Micallef R, Galdes A, Fenech FF. 2001;26(1):21-26. Zinc toxicity: denture adhesives, bone marrow failure and polyneuropathy. ; 10 ( 1 ) zinc as an adjunct to antibiotics for the treatment of common colds Boiteau HL Litoux!, Trossaert M, Asemi Z. Sorensen JA, Andersen O seem to help IBD... After a few weeks, Susan found that she needed a cane to steady herself even to walk a...: 3 of hydroxychloroquine mouse intestine mouse intestine related to kidney disease,... Keen CL, Litt IF, et al ( Accessed 16 June 2009 ) plasma and the various parameters. Gastrointestinal problems such as abdominal pain, bloating, and diarrhea mouth seems to help treat.. J. V. 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